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Tuesday, August 23, 2011

Treatment With Vitamin C Dissolves Toxic Protein Aggregates in Alzheimer's Disease

Treatment With Vitamin C Dissolves Toxic Protein Aggregates in Alzheimer's Disease, but could it work for bvFTD (Frontotemporal Degeneration) also? Ummmmm ...maybe!

It would be a pleasant addition to any diet.
There have been so many outrageous claims made over the years about the benefits of vitamin C that I am very skeptical. It does seem that almost any antioxidant is beneficial in treating tauopathies. Of course, one cannot soak a living brain in orange juice, so a little more research needs to be done on how much, how long, and what forms can be absorbed by humans.

ScienceDaily (Aug. 18, 2011) — Researchers at Lund University have discovered a new function for vitamin C. Treatment with vitamin C can dissolve the toxic protein aggregates that build up in the brain in Alzheimer's disease.
The research findings are now being presented in the Journal of Biological Chemistry.

The brains of people with Alzheimer's disease contain lumps of so-called amyloid plaques which consist of misfolded protein aggregates. They cause nerve cell death in the brain and the first nerves to be attacked are the ones in the brain's memory centre.

"When we treated brain tissue from mice suffering from Alzheimer's disease with vitamin C, we could see that the toxic protein aggregates were dissolved. Our results show a previously unknown model for how vitamin C affects the amyloid plaques," says Katrin Mani, reader in Molecular Medicine at Lund University.

"Another interesting finding is that the useful vitamin C does not need to come from fresh fruit. In our experiments, we show that the vitamin C can also be absorbed in larger quantities in the form of dehydroascorbic acid from juice that has been kept overnight in a refrigerator, for example."

There is at present no treatment that cures Alzheimer's disease, but the research is aimed at treatments and methods to delay and alleviate the progression of the disease by addressing the symptoms.

That antioxidants such as vitamin C have a protective effect against a number of diseases, from the common cold to heart attacks and dementia, has long been a current focus of research.

"The notion that vitamin C can have a positive effect on Alzheimer's disease is controversial, but our results open up new opportunities for research into Alzheimer's and the possibilities offered by vitamin C," says Katrin Mani.

Comments are welcome.


  1. Yes, it does seem that no matter what ails you, some people think Vitamin C is the answer. I tried large doses of Vit. C for a cold and the results were a continuing cold and a lovely rash all over my face. I'm hoping your results will be more productive!

  2. Thanks for the comment Matilda.

    I know the feeling. I also occasionally take Niacin, and it makes my face feel like I have a major case of prickly-heat!