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Wednesday, October 5, 2011

Alzheimer's Might Be Transmissible - Or It May Not Be!

The following story from Science Daily is being reported by nearly every news service.  I am very skeptical for several reasons. First, and foremost, caregivers don't seem to have an abnormally higher risk of developing the disease. Second - they actually transplanted brain tissue. That is akin to transplanting a tumor, and saying cancer is contagious ...oh Wait! Some forms of cancer do seem to be contagious. Hmmm... In any case hopefully it will shed some light on the process, and maybe open some new research pathways into the tauopathies. Here is the whole article:

Alzheimer's Might Be Transmissible in Similar Way as Infectious Prion Diseases, Research Suggests

ScienceDaily (Oct. 4, 2011) — The brain damage that characterizes Alzheimer's disease may originate in a form similar to that of infectious prion diseases such as bovine spongiform encephalopathy (mad cow) and Creutzfeldt-Jakob, according to newly published research by The University of Texas Health Science Center at Houston (UTHealth).

"Our findings open the possibility that some of the sporadic Alzheimer's cases may arise from an infectious process, which occurs with other neurological diseases such as mad cow and its human form, Creutzfeldt-Jakob disease," said Claudio Soto, Ph.D., professor of neurology at The University of Texas Medical School at Houston, part of UTHealth. "The underlying mechanism of Alzheimer's disease is very similar to the prion diseases. It involves a normal protein that becomes misshapen and is able to spread by transforming good proteins to bad ones. The bad proteins accumulate in the brain, forming plaque deposits that are believed to kill neuron cells in Alzheimer's."

The results showing a potentially infectious spreading of Alzheimer's disease in animal models were published in the Oct. 4, 2011 online issue of Molecular Psychiatry, part of the Nature Publishing Group. The research was funded by The George P. and Cynthia W. Mitchell Center for Research in Alzheimer's Disease and Related Brain Disorders at UTHealth.

Alzheimer's disease is a form of progressive dementia that affects memory, thinking and behavior. Of the estimated 5.4 million cases of Alzheimer's in the United States, 90 percent are sporadic. The plaques caused by misshapen aggregates of beta amyloid protein, along with twisted fibers of the protein tau, are the two major hallmarks associated with the disease. Alzheimer's is the sixth leading cause of death in the United States, according to the Alzheimer's Association.

Researchers injected the brain tissue of a confirmed Alzheimer's patient into mice and compared the results to those from injected tissue of a control without the disease. None of the mice injected with the control showed signs of Alzheimer's, whereas all of those injected with Alzheimer's brain extracts developed plaques and other brain alterations typical of the disease.

"We took a normal mouse model that spontaneously does not develop any brain damage and injected a small amount of Alzheimer's human brain tissue into the animal's brain," said Soto, who is director of the Mitchell Center. "The mouse developed Alzheimer's over time and it spread to other portions of the brain. We are currently working on whether disease transmission can happen in real life under more natural routes of exposure."

UTHealth co-authors of the paper are Rodrigo Morales, Ph.D, postdoctoral fellow, and Claudia Duran-Aniotz, research assistant. Other co-authors are Joaquin Castilla, Ph.D., Basque Foundation for Science, Bilbao, Spain; and Lisbell D. Estrada, Ph.D., Universidad Catolica de Chile, Santiago, Chile. Duran-Anoitz is also a doctoral student at the Universidad de los Andes in Santiago, Chile. Soto, Morales, Castilla and Estrada did a portion of the research at The University of Texas Medical Branch at Galveston.

Comments are welcome.


  1. Disturbing. And maybe, because the caregiver is most often the person who is a spouse or other person who has been with the one with bvftd the longest, there is some kind of immunity which happens. Seems unlikely, but who knows.

  2. Thanks for your comment.

    Remember. "Transmissible" does not mean it is "contagious". Injecting brain tissue is a little extreme ; )

  3. Your next! (Oct 14) post talks about a number of possible infectious agents, viruses and bacteria. They could very well be contagious, and a long term low level exposure might lead to immunity. The caregiver need not be injected with brain tissue...